How microRNAs affect kidney transplant rejection
Post-transcriptional regulation of gene expression by microRNAs in antibody-mediated rejection
This study is looking at tiny molecules called microRNAs to understand how they affect kidney transplant rejection, which could help doctors find better ways to prevent or treat rejection for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10896168 on NIH RePORTER |
What this research studies
This research investigates the role of microRNAs in regulating gene expression during chronic antibody-mediated rejection of kidney transplants. By isolating specific microRNAs and their target messenger RNAs, the study aims to create a detailed interaction map that reveals how these molecules influence kidney injury and rejection processes. This innovative approach seeks to enhance our understanding of the biological mechanisms at play in kidney transplant rejection, potentially leading to improved treatment strategies. Patients may benefit from insights gained into how to better manage or prevent rejection episodes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are at risk for chronic antibody-mediated rejection.
Not a fit: Patients who have not undergone kidney transplantation or those with acute rejection episodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing kidney transplant rejection and improving transplant outcomes.
How similar studies have performed: Other studies have shown promise in understanding microRNA roles in various diseases, suggesting that this approach could yield valuable insights into kidney transplant rejection.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Iacomini, John J — Tufts University Boston
- Study coordinator: Iacomini, John J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.