How microRNA affects inflammation and cancer in the colon
MicroRNA control of tumor-promoting inflammation in colon cancer
This study is looking at how a tiny molecule called miR-146a can help reduce inflammation and tumor growth in colon cancer, which could lead to new treatments for patients dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11015006 on NIH RePORTER |
What this research studies
This research investigates the role of microRNA, specifically miR-146a, in controlling inflammation and tumor development in colon cancer. It focuses on how miR-146a can inhibit the signaling pathways that lead to increased levels of interleukin-17 (IL-17), a cytokine associated with poor outcomes in colorectal cancer. By studying mouse models, the research aims to uncover the mechanisms by which miR-146a can prevent inflammation and tumorigenesis, potentially leading to new therapeutic strategies for colon cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer or those at high risk for developing it due to inflammatory conditions.
Not a fit: Patients with non-colorectal cancers or those without any inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve survival rates for colon cancer patients.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can improve outcomes in cancer treatment, suggesting that this approach may also be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gopal, Murugaiyan — Brigham and Women's Hospital
- Study coordinator: Gopal, Murugaiyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.