How microbiomes affect immune responses in sepsis
Official title: Microbiomes regulate neutrophil responses in sepsis
Funded at University of Rochester · NIH-11130058 · Data updated 2026-11-12
This study is looking at how the tiny germs in our bodies, called microbiomes, might help our immune cells respond better during serious infections like sepsis, which can be life-threatening, to see why some people get sicker than others.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | February 3, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $231,000 |
| NIH project number | 1R21AI184402-01A1 |
| Project ID | NIH-11130058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced sepsis or are at high risk for developing sepsis due to infections.
✕Less likely to help
Patients with sepsis caused by non-infectious factors or those who do not have a diverse microbiome may not benefit from this research.
What this research studies
This research investigates the role of microbiomes in regulating neutrophil responses during sepsis, a severe condition caused by infection that can lead to organ failure. The study aims to understand how the diverse compositions of microbiomes in healthy individuals may influence the immune system's response to sepsis. By examining blood samples, researchers will explore whether these microbiomes can 'train' neutrophils, a type of immune cell, to respond differently to inflammation. The findings could help identify why some patients are more susceptible to severe outcomes from sepsis than others.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating sepsis by targeting microbiome interactions.
How similar studies have gone: Other research has shown promising results in understanding the role of microbiomes in immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Kim, Minsoo — University of Rochester
- Study coordinator: Kim, Minsoo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.