How microbes influence cell movement and behavior
Microbial mobilization of the actin cytoskeleton
This study looks at how tiny structures inside our cells, called the actin cytoskeleton, help cells change shape, move, and divide, especially when they interact with harmless microbes, and it hopes to find out how these processes might be linked to diseases like cancer and heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11075811 on NIH RePORTER |
What this research studies
This research investigates the role of the actin cytoskeleton in cellular functions such as shape, migration, and division, particularly in the context of microbial interactions. By studying how non-pathogenic microbes interact with host cells, the research aims to uncover the mechanisms that regulate actin assembly and its impact on cell behavior. This approach could provide insights into various diseases where actin dysfunction plays a role, including cancer metastasis and cardiovascular diseases. The research utilizes advanced techniques to observe these interactions and their effects on cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to actin dysfunction, such as cancer or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to actin dysfunction or those not affected by microbial interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to actin dysfunction.
How similar studies have performed: Previous research has shown that studying microbe-host interactions can significantly enhance our understanding of cellular processes, indicating a promising avenue for this investigation.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Welch, Matthew D — University of California Berkeley
- Study coordinator: Welch, Matthew D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.