How microbes and their hosts interact and evolve together
Molecular mechanisms of evolution at the host-microbe interface
['FUNDING_OTHER'] · UNIVERSITY OF OREGON · NIH-10653883
This study looks at how tiny germs and the animals they live in interact, especially focusing on the proteins that help these germs stick to the animal's surfaces, which can either help keep us healthy or make us sick, and it’s designed for anyone interested in understanding how our immune system fights off infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OREGON (nih funded) |
| Locations | 1 site (EUGENE, UNITED STATES) |
| Trial ID | NIH-10653883 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between microbes and their animal hosts, focusing on how proteins at the host-microbe interface evolve. By studying epithelial surfaces, which are the first point of contact with bacteria, the research aims to understand how these interactions can lead to either beneficial relationships or harmful infections. The project employs a combination of phylogenetic analysis and experimental methods to explore how changes in surface proteins affect bacterial virulence and immune responses. Additionally, it examines the evolution of immune proteins in primates to understand their role in combating bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to bacterial infections or those interested in the immune response to such infections.
Not a fit: Patients with non-infectious diseases or those not affected by bacterial pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating bacterial infections, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding host-microbe interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
EUGENE, UNITED STATES
- UNIVERSITY OF OREGON — EUGENE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARBER, MATTHEW FREDERICK — UNIVERSITY OF OREGON
- Study coordinator: BARBER, MATTHEW FREDERICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Communicable Diseases, Infectious Disease Pathway, Infectious Diseases, Infectious Disorder, Disease