How methylation affects SOX proteins in stem cells and development
Regulation of SOX Proteins by Methylation-dependent Proteolysis in Stem Cells and Development
['FUNDING_R01'] · UNIVERSITY OF NEVADA LAS VEGAS · NIH-10739316
This study is looking at how a specific protein called SOX2 helps keep stem cells healthy and able to turn into different types of cells, which could help us understand and treat conditions like anophthalmia and some cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEVADA LAS VEGAS (nih funded) |
| Locations | 1 site (LAS VEGAS, UNITED STATES) |
| Trial ID | NIH-10739316 on ClinicalTrials.gov |
What this research studies
This research investigates the role of CRL4 ubiquitin ligase complexes in regulating important biological processes, particularly focusing on the SOX2 protein, which is crucial for the self-renewal and pluripotency of embryonic stem cells. By understanding how SOX2 levels are controlled through methylation-dependent proteolysis, the research aims to uncover mechanisms that influence stem cell differentiation and development. The study will involve examining the effects of SOX2 on various cell lineages and its implications in conditions like anophthalmia and certain cancers. Patients may benefit from insights gained regarding stem cell behavior and potential therapeutic targets for related diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with genetic conditions like anophthalmia or those affected by cancers associated with SOX2 dysregulation.
Not a fit: Patients with unrelated genetic disorders or cancers not linked to SOX2 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to stem cell dysfunction and certain cancers.
How similar studies have performed: Other research has shown promising results in understanding the regulation of stem cell proteins, indicating that this approach has potential for success.
Where this research is happening
LAS VEGAS, UNITED STATES
- UNIVERSITY OF NEVADA LAS VEGAS — LAS VEGAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, HUI — UNIVERSITY OF NEVADA LAS VEGAS
- Study coordinator: ZHANG, HUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Cancers