How methamphetamine use affects HIV progression and treatment outcomes
Official title: Relationship between methamphetamine use, viral reservoir dynamics and clinical progression in treated HIV infection
Funded at University of Miami School of Medicine · NIH-11085145 · Data updated 2026-11-12
This study is looking at how using methamphetamine affects HIV treatment and the immune system in men who have sex with men, hoping to find better ways to help those dealing with both HIV and meth use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $632,239 |
| NIH project number | 5R01DA058437-03 |
| Project ID | NIH-11085145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men who have sex with men (MSM) who are living with HIV and have a history of methamphetamine use.
✕Less likely to help
Patients who do not use methamphetamine and are not affected by HIV may not benefit from this research.
What this research studies
This research investigates the impact of methamphetamine (METH) use on the dynamics of HIV viral reservoirs and the clinical progression of HIV in patients receiving treatment. It aims to understand the biological mechanisms by which METH alters immune responses, particularly focusing on monocyte inflammation and its effects on viral suppression. By studying a cohort of men who have sex with men (MSM) who use METH, the research seeks to identify factors that contribute to virologic rebound and faster disease progression despite antiretroviral therapy. The findings could lead to improved treatment strategies for those affected by both METH use and HIV.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for HIV patients who use methamphetamine, potentially improving their health outcomes.
How similar studies have gone: Previous research has indicated that stimulant use can negatively impact HIV treatment outcomes, suggesting that this study builds on established findings rather than exploring a completely novel approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Stevenson, Mario — University of Miami School of Medicine
- Study coordinator: Stevenson, Mario
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.