How methadone affects brain development in human organoids
Effect of methadone on the developmental properties of human brain organoids
This study is looking at how methadone might affect the growth of tiny brain models that help us understand early brain development, especially for babies whose moms use methadone during pregnancy, so we can learn more about any risks to their brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11034069 on NIH RePORTER |
What this research studies
This research investigates the impact of methadone on the development of human brain organoids, which are 3D models that mimic early human brain development. By examining these organoids, researchers aim to understand how methadone exposure may disrupt normal brain development, particularly in the context of opioid dependence during pregnancy. The study utilizes advanced techniques to analyze cellular and molecular changes in the brain organoids, focusing on synaptic transmission and plasticity. This research is crucial for uncovering the potential risks associated with methadone use in pregnant women and its effects on fetal brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are using methadone for opioid dependence.
Not a fit: Patients who are not pregnant or those who are not using methadone for opioid dependence may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of the effects of methadone on fetal brain development, ultimately improving outcomes for infants born to opioid-dependent mothers.
How similar studies have performed: While opioid effects on brain development have been studied, the use of 3D brain organoids for this specific investigation is a novel approach that has not been extensively tested.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Haddad, Gabriel G — University of California, San Diego
- Study coordinator: Haddad, Gabriel G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.