How metformin may protect lungs from damage caused by cigarette smoke
Official title: Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolism
Funded at Baylor College of Medicine · NIH-11000124 · Data updated 2026-11-12
This study is looking at whether metformin, a medication for type 2 diabetes, can help protect your lungs from damage caused by cigarette smoke and improve lung health, especially for those who might be at risk for conditions like emphysema.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $796,760 |
| NIH project number | 1R01HL171622-01A1 |
| Project ID | NIH-11000124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with emphysema or chronic obstructive pulmonary disease (COPD), particularly those with a history of cigarette smoking.
✕Less likely to help
Patients who do not smoke and do not have lung-related conditions may not receive any benefit from this research.
What this research studies
This research investigates the protective effects of metformin, a medication commonly used for type 2 diabetes, against lung damage caused by cigarette smoke. The study focuses on how metformin can improve the function of specific lung cells, known as alveolar type 2 cells, which are essential for lung health and repair. By enhancing the metabolism of these cells and reducing oxidative stress, the research aims to demonstrate that metformin can help prevent or mitigate conditions like emphysema. Patients may be involved in trials to assess the effectiveness of metformin in improving lung function and overall health.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from lung diseases related to smoking, potentially improving their quality of life.
How similar studies have gone: Previous studies have shown promising results regarding the protective effects of metformin on lung health, suggesting that this approach may be effective.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Polverino, Francesca — Baylor College of Medicine
- Study coordinator: Polverino, Francesca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.