How metformin may protect lungs from damage caused by cigarette smoke
Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolism
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11000124
This study is looking at whether metformin, a medication for type 2 diabetes, can help protect your lungs from damage caused by cigarette smoke and improve lung health, especially for those who might be at risk for conditions like emphysema.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11000124 on ClinicalTrials.gov |
What this research studies
This research investigates the protective effects of metformin, a medication commonly used for type 2 diabetes, against lung damage caused by cigarette smoke. The study focuses on how metformin can improve the function of specific lung cells, known as alveolar type 2 cells, which are essential for lung health and repair. By enhancing the metabolism of these cells and reducing oxidative stress, the research aims to demonstrate that metformin can help prevent or mitigate conditions like emphysema. Patients may be involved in trials to assess the effectiveness of metformin in improving lung function and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with emphysema or chronic obstructive pulmonary disease (COPD), particularly those with a history of cigarette smoking.
Not a fit: Patients who do not smoke and do not have lung-related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from lung diseases related to smoking, potentially improving their quality of life.
How similar studies have performed: Previous studies have shown promising results regarding the protective effects of metformin on lung health, suggesting that this approach may be effective.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POLVERINO, FRANCESCA — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: POLVERINO, FRANCESCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus