How metformin affects energy production and aging
Bioenergetics of Metformin Action and Aging
['FUNDING_R01'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-11205657
This study is looking at how metformin, a diabetes medication, affects energy production in our cells and how it might help us age healthier, with hopes of discovering benefits for cancer prevention and heart health too, so patients can learn more about how their metabolism impacts the medicine's effectiveness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-11205657 on ClinicalTrials.gov |
What this research studies
This research investigates how metformin, a medication commonly used for diabetes, influences energy production in cells and its effects on aging. The study aims to uncover the molecular mechanisms behind metformin's benefits, which may extend beyond diabetes to include cancer prevention, cardiovascular health, and overall longevity. By using advanced laboratory techniques, researchers will explore how metformin interacts with aging processes and mitochondrial function, potentially leading to new insights into healthy aging. Patients may gain a better understanding of how their metabolic state influences the effectiveness of metformin.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diabetes or those interested in the effects of metformin on aging and health.
Not a fit: Patients who do not take metformin or are not interested in its effects on aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for using metformin to enhance health span and longevity in patients.
How similar studies have performed: Previous research has shown promising results regarding metformin's effects on health and aging, suggesting that this approach has potential for significant findings.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEUFER, P DARRELL — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: NEUFER, P DARRELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.