How metal ions influence virus behavior and immune responses
Official title: From humans and eukaryotes to viruses and pathogens; how transition metals shape catalysis and allostery
Funded at Brandeis University · NIH-11011599 · Data updated 2026-11-12
This study is looking at how certain proteins and metal ions help viruses interact with our bodies, which could lead to new treatments for viral infections like Hepatitis E and Foot and Mouth Disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $502,043 |
| NIH project number | 1R35GM156452-01 |
| Project ID | NIH-11011599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by viral infections, particularly those with Hepatitis E or Foot and Mouth Disease.
✕Less likely to help
Patients with non-viral infections or those not affected by the specific viruses being studied may not benefit from this research.
What this research studies
This research investigates the role of metalloproteins and metal ions in the interaction between viruses and their hosts, focusing on how these elements affect enzyme functions critical for immune responses and viral replication. The project aims to understand the mechanisms by which metal ions regulate viral proteases and other enzymes involved in the host-pathogen interface. By exploring these interactions, the research seeks to uncover potential targets for new treatments against viral infections, particularly for diseases like Hepatitis E and Foot and Mouth Disease.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapeutic strategies for viral infections by targeting the metal-dependent activities of viral enzymes.
How similar studies have gone: While the role of metalloproteins in viral infections is an emerging field, there have been preliminary successes in understanding similar mechanisms in other contexts, suggesting potential for breakthroughs.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Pandelia, Maria-Eirini — Brandeis University
- Study coordinator: Pandelia, Maria-Eirini
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.