How metabolites in different organs affect cancer spread
Project 3: The role of microenvironmental metabolites on metastatic progression
This study looks at how cancer cells change their behavior to survive and grow in new parts of the body, especially when they face tough conditions like low nutrients and oxygen, with the goal of finding better ways to treat metastatic cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11190561 on NIH RePORTER |
What this research studies
This research investigates how the environment of different organs influences the metabolism of cancer cells during the process of metastasis. It focuses on understanding how cancer cells adapt their metabolic processes to survive and grow in new locations within the body, particularly when faced with nutrient and oxygen shortages. By examining the interactions between cancer cells and their surrounding tissues, the research aims to uncover the mechanisms that allow cancer cells to thrive despite these challenges. This knowledge could lead to improved strategies for targeting metastatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with metastatic cancer who are experiencing challenges related to tumor growth in distant organs.
Not a fit: Patients with localized cancer that has not spread to other organs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better target metastatic cancer by understanding how to disrupt the metabolic adaptations of cancer cells.
How similar studies have performed: Other research has shown promising results in understanding cancer metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Birsoy, Kivanc — Rockefeller University
- Study coordinator: Birsoy, Kivanc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.