How metabolism influences the transition of stem cells from a naive state to differentiation
Metabolic control of exit from naïve pluripotency
This study is looking at how changes in the way cells use energy can help embryonic stem cells grow and change into different types of cells, which is important for understanding how our bodies develop and how diseases can happen.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11099784 on NIH RePORTER |
What this research studies
This research investigates how changes in cellular metabolism affect the ability of embryonic stem cells to transition from a naive pluripotent state to differentiated states. By examining the metabolic pathways and the role of specific metabolites, the study aims to uncover the mechanisms that drive this critical process in cell development. The researchers will utilize genetic and pharmacological approaches to analyze how fluctuations in metabolite levels can influence gene expression and cell fate decisions. This work could provide insights into the fundamental processes of development and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to stem cell function or differentiation disorders.
Not a fit: Patients with fully differentiated cells or those not affected by stem cell-related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for stem cell therapy and regenerative medicine by enhancing our understanding of cell differentiation.
How similar studies have performed: Other research has shown promising results in understanding metabolic control of cell fate, indicating that this approach has potential for significant advancements.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Jackson, Benjamin Tonnu — Weill Medical Coll of Cornell Univ
- Study coordinator: Jackson, Benjamin Tonnu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.