How metabolism affects muscle stem cell health and function
Official title: Metabolic regulation of muscle satellite cell homeostasis
Funded at Duke University · NIH-11169576 · Data updated 2026-11-12
This study is looking at how our body's metabolism affects special muscle cells that help with muscle growth and repair, especially after an injury, to find out how these cells can be better supported for healthier muscles.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $531,747 |
| NIH project number | 7R01DK132819-03 |
| Project ID | NIH-11169576 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be experiencing muscle injuries or conditions affecting muscle regeneration.
✕Less likely to help
Patients with non-muscle related conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of metabolism in regulating muscle satellite cells, which are essential for muscle growth, maintenance, and repair. The study focuses on understanding how these cells transition between different states, such as quiescence and activation, particularly in response to muscle injury. By examining the cellular mechanisms and signaling pathways involved, the research aims to uncover how lipid droplets influence the behavior of muscle stem cells. This could lead to new insights into muscle regeneration and overall muscle health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for muscle injuries and degenerative conditions, enhancing recovery and muscle function.
How similar studies have gone: Other research has shown promising results in understanding the role of metabolism in stem cell function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kuang, Shihuan — Duke University
- Study coordinator: Kuang, Shihuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.