How metabolism affects heart failure, liver cancer, and undernutrition
Metabolic Basis of Disease - Phase 2
This center supports teams working to understand how metabolic changes drive heart failure with preserved ejection fraction, liver cancer, and undernutrition so patients with these conditions may benefit from new discoveries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project ID | NIH-11093207 on NIH RePORTER |
What this research studies
This award funds a center that brings together early-career investigators, shared laboratory cores, and technical resources to study metabolic drivers of three disease areas: HFpEF, hepatocellular carcinoma, and undernutrition/iron metabolism. The center provides animal models, genomics, imaging, and molecular biology support to the research teams and mentors new investigators. Most work is preclinical in cells and animal models with molecular studies aimed at identifying pathways and potential targets. Over time the goal is to move promising findings toward human-relevant tests or treatments.
Who could benefit from this research
Good fit: People living with HFpEF, hepatocellular carcinoma, or undernutrition/iron disorders who are willing to provide clinical samples or consider future clinical trials would be most relevant.
Not a fit: Patients with unrelated conditions or those seeking immediate clinical therapies are unlikely to receive direct, short-term benefit from this largely preclinical and infrastructure-focused center.
Why it matters
Potential benefit: If successful, this work could reveal metabolism-based targets or biomarkers that lead to new treatments or diagnostics for heart failure, liver cancer, or malnutrition-related conditions.
How similar studies have performed: Center-based metabolic research has previously identified promising targets and biomarkers, but translating those lab findings into treatments typically takes substantial additional work.
Where this research is happening
Baton Rouge, United States
- Lsu Pennington Biomedical Research Ctr — Baton Rouge, United States (Active)
Researchers
- Principal investigator: Stephens, Jacqueline M — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Stephens, Jacqueline M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.