How metabolism affects gene regulation in the aging eye
Chromatin connects metabolism to circadian gene regulation in the aging eye
This study looks at how changes in metabolism affect gene activity in the aging eye, using fruit flies to understand how a key molecule might influence eye health and contribute to age-related vision problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11010336 on NIH RePORTER |
What this research studies
This research investigates the relationship between metabolism and gene regulation in the aging eye, focusing on how changes in metabolic pathways impact the epigenome. It examines the role of S-adenosylmethionine (SAM), a key molecule derived from methionine, in regulating histone and DNA methylation. By studying the aging Drosophila eye, the research aims to uncover how alterations in methionine metabolism lead to changes in gene expression and contribute to retinal degeneration. The findings could provide insights into the mechanisms of age-related eye diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related changes in vision or those at risk for retinal degeneration.
Not a fit: Patients with retinal degeneration due to non-age-related factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related retinal degeneration.
How similar studies have performed: Previous research has shown that metabolic interventions can influence aging processes, suggesting potential for success in this area.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Weake, Vikki Marie — Purdue University
- Study coordinator: Weake, Vikki Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.