How metabolism affects aging and stress responses in cells
Dual transcriptional programs coordinate lipogenic and membrane stress responsive programs in C. elegans
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11030808
This study is looking at how certain substances in our bodies, like phosphatidylcholine, affect how our cells handle stress as we age, using tiny worms and human cells to learn more about the aging process.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11030808 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between metabolism and aging, focusing on how certain metabolites influence cellular stress responses. By studying a long-lived model organism, C. elegans, and human cell-based assays, the research aims to understand how the production of specific molecules, like phosphatidylcholine, impacts cellular functions related to aging. The study explores the mechanisms by which these metabolites regulate stress responses in cellular structures, particularly the Golgi apparatus, and how this may affect aging processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging or those affected by age-related diseases such as Alzheimer's.
Not a fit: Patients with acute conditions unrelated to aging or metabolic processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how metabolic regulation can influence aging and potentially improve health outcomes for age-related conditions.
How similar studies have performed: Other research has shown promising results in understanding metabolic pathways and their effects on aging, suggesting that this approach could yield valuable insights.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALKER, AMY KAROL — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: WALKER, AMY KAROL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome