How metabolism affects aging and inflammation in the colon
Metabolic Regulation of Colonic Senescence and Pathological Implications: Epithelial and Microbial Interactions
['FUNDING_R01'] · UNIVERSITY OF CHICAGO · NIH-11041071
This study is looking at how a molecule called acetyl-CoA affects aging and inflammation in the colon, which could help us understand and treat related health issues for both people and mice.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11041071 on ClinicalTrials.gov |
What this research studies
This research investigates how metabolic processes influence cellular aging and inflammation in the colon. It focuses on the role of a specific molecule, acetyl-CoA, in driving cellular senescence, a state where cells stop dividing and can contribute to inflammation and tissue damage. By studying both human patients and mouse models, the research aims to uncover the mechanisms behind age-related and age-unrelated senescence in the colon, which could lead to better understanding and treatment of related diseases. The approach includes examining the secretion of inflammatory factors and their impact on health.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing gastrointestinal issues or those with inflammatory bowel disease.
Not a fit: Patients who are younger and do not have any gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related diseases and inflammatory conditions affecting the colon.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular senescence in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, YAN CHUN — UNIVERSITY OF CHICAGO
- Study coordinator: LI, YAN CHUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.