How metabolic signals and the circadian clock affect protein synthesis
Regulation of protein synthesis by metabolic signals and the circadian clock
This study looks at how different signals like light and temperature affect how cells make proteins, using a common plant as a model, to help us learn more about a specific pathway that could lead to better treatments for health issues related to cell growth and function.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project ID | NIH-10202987 on NIH RePORTER |
What this research studies
This research investigates how various signals, such as light, temperature, and metabolic markers, influence the process of protein synthesis in cells. By studying the model plant Arabidopsis thaliana, researchers aim to understand the role of a specific signaling pathway known as the TOR-S6 kinase pathway in regulating protein production. The project employs advanced molecular and biochemical techniques to explore how these signals are integrated and how they affect cellular functions. Patients may benefit from insights gained about protein synthesis that could lead to new treatments for conditions related to cellular growth and function.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to protein synthesis disorders or metabolic dysfunction.
Not a fit: Patients with conditions unrelated to protein synthesis or metabolic signaling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to protein synthesis and cellular function.
How similar studies have performed: Previous research has shown success in understanding protein synthesis regulation through similar signaling pathways, indicating a promising avenue for further exploration.
Where this research is happening
Knoxville, United States
- University of Tennessee Knoxville — Knoxville, United States (Active)
Researchers
- Principal investigator: Von Arnim, Albrecht G. — University of Tennessee Knoxville
- Study coordinator: Von Arnim, Albrecht G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.