How metabolic factors influence the development of blood vessels
Official title: Metabolic control of human endothelial development via the COUP-TF/1-deoxysphingosine axis
Funded at University of Georgia · NIH-11078774 · Data updated 2026-11-12
This study is looking at how certain factors help build the cells that make up blood vessels, which is important for healing and fighting diseases like heart problems and cancer, and it could lead to new treatments that help wounds heal better or slow down tumor growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | May 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $511,305 |
| NIH project number | 5R01HL173931-02 |
| Project ID | NIH-11078774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with conditions related to poor wound healing, cardiovascular diseases, or certain types of cancer.
✕Less likely to help
Patients with stable, non-vascular related conditions may not receive any benefit from this research.
What this research studies
This research investigates the role of specific metabolic factors in the development of endothelial cells, which are crucial for forming blood vessels. By examining how the transcription factor NR2F2 regulates these cells, the study aims to uncover the mechanisms that control blood vessel formation and function. The research utilizes advanced 3-D modeling techniques to simulate and analyze these processes, potentially leading to new therapeutic strategies for conditions like heart disease and cancer. Patients may benefit from insights gained about how to enhance wound healing or inhibit tumor growth through targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve wound healing and inhibit tumor growth in patients.
How similar studies have gone: Other research has shown promising results in targeting metabolic pathways for vascular development, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Ivanova, Natalia B — University of Georgia
- Study coordinator: Ivanova, Natalia B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.