How metabolic changes affect inflammation in brain injuries
Official title: Metabolic regulation of Neutrophil Extracellular Traps (NETs) in TBI
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11134030 · Data updated 2026-11-12
This study is looking at how changes in brain metabolism and inflammation after a traumatic brain injury might be connected, and it hopes to find new ways to reduce inflammation and protect the brain, which could help people recover better after such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $453,860 |
| NIH project number | 1R01NS138370-01A1 |
| Project ID | NIH-11134030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are seeking innovative treatment options.
✕Less likely to help
Patients with non-traumatic brain injuries or those who do not have access to the study locations may not benefit from this research.
What this research studies
This research investigates the relationship between metabolic changes in the brain and inflammation following traumatic brain injury (TBI). By using animal models, the study examines how the loss of AMPKα activity leads to increased neutrophil activation and the formation of Neutrophil Extracellular Traps (NETs), which contribute to inflammation. The researchers aim to explore the potential of AMPK activators to reduce inflammation and promote neuroprotection, ultimately identifying optimal treatment strategies for TBI. Patients may benefit from insights gained about new therapeutic approaches that could extend the time frame for effective treatment after brain injuries.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery and outcomes for patients with traumatic brain injuries.
How similar studies have gone: Previous research has shown promising results in using metabolic modulation to influence inflammation and recovery in brain injuries, suggesting that this approach may be effective.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Ahmed, Mohammad Ejaz — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Ahmed, Mohammad Ejaz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.