How metabolic acidosis affects muscle health and endurance in people with chronic kidney disease
Impact of metabolic acidosis on muscle mitochondrial energetics, metabolic health and physical endurance in persons with chronic kidney disease
This study looks at how a condition called metabolic acidosis affects muscle health and energy in people with chronic kidney disease, especially older adults, to find ways to help them stay strong and active.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10918348 on NIH RePORTER |
What this research studies
This research investigates the effects of metabolic acidosis on muscle mitochondrial function and overall metabolic health in individuals with chronic kidney disease (CKD). It focuses on understanding how metabolic acidosis contributes to muscle wasting and reduced physical endurance, which are critical for maintaining independence in older adults. The study employs advanced imaging techniques, such as 31Phosphorus Magnetic Resonance Spectroscopy, to assess muscle metabolism and energy production. By exploring these relationships, the research aims to identify potential interventions to improve muscle health and physical performance in CKD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly older adults who prioritize maintaining their physical independence.
Not a fit: Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing muscle health and physical endurance in patients with chronic kidney disease.
How similar studies have performed: Previous research has indicated that addressing metabolic acidosis can positively impact muscle function in CKD, suggesting that this approach may yield beneficial results.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Roshanravan, Baback — University of California at Davis
- Study coordinator: Roshanravan, Baback
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.