How metabolic acidosis affects muscle health and endurance in people with chronic kidney disease
Official title: Impact of metabolic acidosis on muscle mitochondrial energetics, metabolic health and physical endurance in persons with chronic kidney disease
Funded at University of California at Davis · NIH-10918348 · Data updated 2026-11-12
This study looks at how a condition called metabolic acidosis affects muscle health and energy in people with chronic kidney disease, especially older adults, to find ways to help them stay strong and active.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 18, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $621,333 |
| NIH project number | 5R01DK129793-04 |
| Project ID | NIH-10918348 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly older adults who prioritize maintaining their physical independence.
✕Less likely to help
Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
What this research studies
This research investigates the effects of metabolic acidosis on muscle mitochondrial function and overall metabolic health in individuals with chronic kidney disease (CKD). It focuses on understanding how metabolic acidosis contributes to muscle wasting and reduced physical endurance, which are critical for maintaining independence in older adults. The study employs advanced imaging techniques, such as 31Phosphorus Magnetic Resonance Spectroscopy, to assess muscle metabolism and energy production. By exploring these relationships, the research aims to identify potential interventions to improve muscle health and physical performance in CKD patients.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing muscle health and physical endurance in patients with chronic kidney disease.
How similar studies have gone: Previous research has indicated that addressing metabolic acidosis can positively impact muscle function in CKD, suggesting that this approach may yield beneficial results.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Roshanravan, Baback — University of California at Davis
- Study coordinator: Roshanravan, Baback
Related research
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-
How acid balance affects muscle energy and endurance in people with chronic kidney disease
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-
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.