How menopause affects gene regulation and metabolic health in women
Official title: Changes in cardiometabolic tissue gene regulation and omics profiles with menopause
Funded at University of California, San Francisco · NIH-10872907 · Data updated 2026-11-12
This study is looking at how menopause affects hormones and body health, especially heart and metabolism, using mice to see what changes happen in their bodies, which could help us understand why women might face more health risks after menopause.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $450,688 |
| NIH project number | 1R21AG086775-01 |
| Project ID | NIH-10872907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postmenopausal women experiencing cardiovascular or metabolic health issues.
✕Less likely to help
Patients who are premenopausal or do not have any cardiovascular or metabolic conditions may not benefit from this research.
What this research studies
This research investigates the hormonal and physiological changes that occur during menopause and their impact on cardiovascular and metabolic health. By using a mouse model that simulates menopause, the study aims to identify changes in gene expression and chromatin accessibility in key tissues such as the liver, adipose tissue, and aorta. The research will compare menopausal mice with control groups to understand how these changes contribute to increased health risks in women after menopause. The findings could provide insights into the molecular mechanisms behind the worsening of health conditions during this transition.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cardiovascular and metabolic diseases in postmenopausal women.
How similar studies have gone: Previous research has shown that hormonal changes during menopause significantly affect health, but this specific approach to studying gene regulation is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Theusch, Elizabeth — University of California, San Francisco
- Study coordinator: Theusch, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.