How memories form and become long-lasting
Modeling the Molecular Networks that Underlie the Formation and Consolidation of Memory
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11247508
This work uses computer-designed training schedules and targeted drugs to help adults build stronger, longer-lasting memories.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11247508 on ClinicalTrials.gov |
What this research studies
Researchers combine computer models of the molecular chemistry of memory with lab experiments to design better training schedules and drug approaches. They will test these ideas in three systems: a simple sea slug model of long-term sensitization, fear learning and extinction, and inhibitory avoidance learning. The models focus on timing and overlap of key molecules such as PKA and ERK and how those signals turn on genes needed for long-term memory. The team will use the computational predictions to guide pharmacology and behavioral training to try to strengthen memory and rescue deficits.
Who could benefit from this research
Good fit: Adults with memory problems or at risk for memory decline would be the likely candidates for future trials based on this work.
Not a fit: People whose memory loss is due to extensive structural brain damage or conditions unrelated to molecular memory mechanisms may not benefit from these approaches.
Why it matters
Potential benefit: If successful, this could lead to new training programs and drug approaches that help people form and retain long-term memories.
How similar studies have performed: Previous animal studies by this group showed promising memory enhancement using computationally designed protocols, but human benefit is not yet proven.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BYRNE, JOHN H — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: BYRNE, JOHN H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.