How Membrane Proteins Are Built in Our Cells
Membrane protein biogenesis at the ER
This work helps us understand how important proteins in our cells are made, which is key to many human diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11112301 on NIH RePORTER |
What this research studies
Our bodies rely on special proteins within cell membranes to perform vital tasks like receiving signals or transporting substances. When these proteins don't form correctly, it can lead to various health problems. This project aims to uncover the detailed steps involved in building these crucial membrane proteins, especially those with complex structures. Researchers are using advanced techniques to study how these proteins are inserted and folded within human cells. By understanding this fundamental process, we hope to gain insights into why some diseases occur.
Who could benefit from this research
Good fit: Patients with diseases linked to problems in how membrane proteins are made or folded could potentially benefit from future treatments developed from this basic understanding.
Not a fit: Patients whose conditions are not related to membrane protein formation or function may not directly benefit from this specific basic science work.
Why it matters
Potential benefit: If successful, this fundamental knowledge could lead to new ways to address diseases caused by faulty membrane proteins.
How similar studies have performed: While the general field of protein biogenesis is established, this project focuses on a newly discovered mechanism for multi-pass membrane proteins, suggesting a novel approach.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Keenan, Robert J — University of Chicago
- Study coordinator: Keenan, Robert J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.