How membrane fats control receptor proteins
Biophysical Mechanisms of Lipid-Receptor Interactions
['FUNDING_OTHER'] · UNIVERSITY OF FLORIDA · NIH-11259703
This work looks at how fats in cell membranes change the shape and signals of human receptor proteins to help us understand diseases and improve treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11259703 on ClinicalTrials.gov |
What this research studies
Researchers will use powerful lab methods, especially NMR spectroscopy, to watch how membrane lipids interact with human receptor proteins and change their shapes and activity. They will combine those physical measurements with drug-response and signaling tests to link molecular changes to cellular effects. The team aims to define general rules for lipid–receptor interactions and move toward seeing these events inside human cells and tissues. Results could guide better drug design by revealing how the membrane environment alters receptor behavior.
Who could benefit from this research
Good fit: People with conditions tied to receptor signaling (for example many heart, lung, metabolic, or nervous system disorders) or those willing to donate blood or tissue samples for lab studies would be most relevant to this work.
Not a fit: Patients needing immediate clinical treatments for their condition are unlikely to receive direct or immediate benefit from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could help design more effective and precise drugs that target receptor proteins with fewer side effects.
How similar studies have performed: Prior laboratory work from this team showed new ways lipids shape receptor behavior, so the approach builds on successful basic-science findings but clinical translation remains early.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EDDY, MATTHEW THOMAS — UNIVERSITY OF FLORIDA
- Study coordinator: EDDY, MATTHEW THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.