How mechanical tension affects scar formation in humans
Differential changes in energy metabolism in response to mechanical tension give rise to human scaring heterogeneity
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11056837
This study is looking at how the amount of pressure on healing skin affects how scars form, so we can better understand why some people get worse scars than others and find ways to help improve healing and reduce scarring.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11056837 on ClinicalTrials.gov |
What this research studies
This research investigates how different levels of mechanical tension during skin healing can lead to varying degrees of scar formation in humans. By examining the energy metabolism of fibroblasts, the cells responsible for wound healing, the study aims to understand why some individuals develop more severe scars than others. The researchers will analyze how biomechanical forces influence cellular responses and energy demands, potentially leading to new strategies for improving wound healing and reducing scarring. The approach includes studying the metabolic shifts in fibroblasts from individuals with different scarring phenotypes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced skin injuries and exhibit varying degrees of scarring.
Not a fit: Patients with no history of skin injuries or those who do not develop scars may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for wound healing that minimize scarring.
How similar studies have performed: Previous research has shown promising results in understanding the role of mechanical forces in wound healing, suggesting that this approach could lead to significant advancements.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BALAJI, SWATHI — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: BALAJI, SWATHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.