How mechanical stretching affects lung scarring in mice
Impact of mechanical stretch on the progression of pulmonary fibrosis in mouse bleomycin model
This study is looking at how stretching of the lungs during breathing affects the worsening of pulmonary fibrosis, especially in older mice, to help find better treatments for this lung condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10791480 on NIH RePORTER |
What this research studies
This research investigates the role of mechanical stretch in the progression of pulmonary fibrosis, a serious lung condition, using a mouse model. The study focuses on understanding why certain areas of the lung are more affected by fibrosis than others, particularly in older mice. By examining the effects of lung expansion during breathing, the researchers aim to uncover mechanisms that could lead to better treatments for this disease. The approach includes analyzing gene expressions and lung tissue responses to mechanical forces.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who are at higher risk for pulmonary fibrosis.
Not a fit: Patients with pulmonary fibrosis who are younger than 65 or those with other underlying lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating pulmonary fibrosis in patients.
How similar studies have performed: Previous studies have shown that mechanical forces can influence lung repair and fibrosis, suggesting that this approach may yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Huang, Yong — University of Virginia
- Study coordinator: Huang, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.