How mechanical stresses affect the nucleus in breast cancer
Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmittedby the LINC Complex
This study is looking at how certain forces in our cells might affect the growth and spread of breast cancer, and it hopes to find new ways to treat the disease by understanding these changes better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Engineering Experiment Station NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10804721 on NIH RePORTER |
What this research studies
This research investigates how mechanical forces transmitted by the LINC complex, which connects the nucleus to the cytoskeleton, may influence the development and progression of breast cancer. By examining the alterations in the LINC complex due to mutations, the study aims to understand how these changes affect nuclear positioning, gene expression, and cancer cell migration. The research will involve detailed analysis of the mechanical stresses in normal and cancerous breast epithelial cells, as well as the impact on the organization of the genome. Patients may benefit from insights that could lead to new therapeutic strategies targeting these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with mutations affecting the LINC complex.
Not a fit: Patients with non-breast cancers or those without mutations in the LINC complex may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the mechanical aspects of cancer cell behavior, potentially improving outcomes for breast cancer patients.
How similar studies have performed: While the specific approach of examining the LINC complex in breast cancer is novel, similar studies have shown that mechanical forces play a significant role in cancer progression.
Where this research is happening
College Station, United States
- Texas Engineering Experiment Station — College Station, United States (Active)
Researchers
- Principal investigator: Lele, Tanmay P. — Texas Engineering Experiment Station
- Study coordinator: Lele, Tanmay P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.