How mechanical stress affects tissue changes in Crohn's disease
Pathogenic Role of Mechanical Stress in Fibrosis and Tissue Remodeling in Crohn's Disease
This study is looking at how physical stress on the intestines might lead to complications in people with Crohn's disease, especially the narrowing of the intestines, and it hopes to find new ways to treat this issue beyond just using anti-inflammatory medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10549370 on NIH RePORTER |
What this research studies
This research investigates the role of mechanical stress in the development of fibrosis and tissue remodeling in patients with Crohn's disease. It focuses on understanding how mechanical forces contribute to stricture formation, which is a common complication in severe cases of the disease. By using a rodent model, the researchers are examining the biological responses in colon smooth muscle cells to mechanical stress, aiming to identify potential new treatment targets beyond traditional anti-inflammatory approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with severe Crohn's disease who experience complications such as strictures.
Not a fit: Patients with mild Crohn's disease or those who do not experience strictures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent or reduce stricture formation in Crohn's disease, improving patient outcomes.
How similar studies have performed: While the specific focus on mechanical stress in Crohn's disease is relatively novel, similar approaches in understanding tissue remodeling have shown promise in other conditions.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Shi, Xuan-Zheng Peter — University of Texas Med Br Galveston
- Study coordinator: Shi, Xuan-Zheng Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.