How mechanical load affects heart cell function
The Functional Connectome of the Mechanically Loaded Cardiomyocyte
This study is looking at how the pressure and strain on heart cells affect how they work and beat, which could help us understand heart function better and find new ways to treat heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10534247 on NIH RePORTER |
What this research studies
This research investigates how mechanical load influences the way heart cells, known as cardiomyocytes, function and contract. By examining the interactions between various signaling pathways and ion channels, the study aims to understand how these cells adapt to changes in load. The researchers will develop a new mathematical model that allows for simultaneous changes in multiple parameters, providing a more comprehensive view of cellular responses. This approach could lead to better insights into heart function and potential treatments for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart conditions, particularly those experiencing heart failure or related cardiac issues.
Not a fit: Patients with non-cardiac related health issues or those without any heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart failure by enhancing our understanding of heart cell mechanics.
How similar studies have performed: Other research has shown success in understanding heart cell mechanics, but this approach using a Functional Connectome is innovative and may provide new insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Izu, Leighton T. — University of California at Davis
- Study coordinator: Izu, Leighton T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.