How mechanical forces influence fetal development timing
Mechanical Clocks During Fetal Development
['FUNDING_OTHER'] · PRINCETON UNIVERSITY · NIH-10895993
This study looks at how physical forces in the body help time the growth of a baby’s organs, especially the lungs, during pregnancy, and it aims to uncover how these forces might influence health later on, which could help improve care for patients with congenital issues or chronic diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-10895993 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mechanical forces in regulating the timing of fetal development, focusing on how these forces affect the growth and formation of organs. By studying the embryonic mammalian lung, the researchers aim to understand how fluid pressure influences the development of tissues and organs during critical stages of pregnancy. The approach involves examining the interactions between mechanical signals and biochemical processes that guide organ development, which could lead to insights into congenital defects and chronic diseases. Patients may benefit from a better understanding of how developmental timing impacts health outcomes later in life.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include pregnant individuals and their unborn children, particularly those at risk for congenital abnormalities.
Not a fit: Patients with fully developed organs and no history of congenital defects or chronic diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for congenital birth defects and chronic diseases linked to developmental timing.
How similar studies have performed: While the concept of mechanical influences on development is emerging, this specific approach is relatively novel and has not been extensively tested in prior research.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NELSON, CELESTE M — PRINCETON UNIVERSITY
- Study coordinator: NELSON, CELESTE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus