How mechanical forces affect blood vessel growth in heart conditions
Mechanical Control of Coronary Angiogenesis in Myocardial Adaptation to Ischemia
This study is looking at how pressure in the heart affects the growth of new blood vessels when someone has heart issues, and it’s exploring whether a specific protein can help improve blood flow, which could lead to better treatments for heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project ID | NIH-10447211 on NIH RePORTER |
What this research studies
This research investigates how mechanical forces in the heart can hinder the growth of new blood vessels during conditions like ischemia and hypertrophy, which can lead to heart failure. The study aims to understand the role of a specific ion channel, TRPV4, in endothelial cells and how its absence may enhance blood vessel formation. By using both laboratory and animal models, the researchers will explore the relationship between mechanical stress and coronary angiogenesis, potentially leading to new therapeutic strategies for heart disease. Patients may benefit from insights gained about improving blood flow in the heart.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing ischemia or heart failure, particularly those with left ventricular hypertrophy.
Not a fit: Patients with stable heart conditions that do not involve ischemia or significant hypertrophy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance blood vessel growth in patients with heart conditions, potentially improving heart function and outcomes.
How similar studies have performed: Previous research has shown that targeting mechanosensitive pathways can influence angiogenesis, suggesting potential for success in this novel approach.
Where this research is happening
Toledo, United States
- University of Toledo Health Sci Campus — Toledo, United States (Active)
Researchers
- Principal investigator: Thodeti, Charles K — University of Toledo Health Sci Campus
- Study coordinator: Thodeti, Charles K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.