How mechanical forces affect blood cell production in the bone marrow
Official title: Mechanical regulation of hematopoiesis
Funded at Ut Southwestern Medical Center · NIH-10997137 · Data updated 2026-11-12
This study is looking at how exercise helps your body make healthy blood cells and keeps your bones strong, focusing on a special channel in your cells that plays a key role in this process.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32HL168918-01A1 |
| Project ID | NIH-10997137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting blood cell production or bone health, such as anemia or osteoporosis.
✕Less likely to help
Patients with stable blood cell production and healthy bone density may not receive significant benefits from this research.
What this research studies
This research investigates how mechanical loading, such as from exercise, influences the production of blood cells in the bone marrow. It focuses on specific cells that respond to mechanical stress and how this affects both blood cell formation and bone health. The study will explore the role of a particular ion channel, TREK1, in regulating these processes under normal physiological conditions. By understanding these mechanisms, the research aims to identify how physical activity can enhance blood and bone health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving blood cell production and bone health through exercise and mechanical stimulation.
How similar studies have gone: Previous research has shown that mechanical loading can positively influence bone and blood health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Shirazi, Jasmine — Ut Southwestern Medical Center
- Study coordinator: Shirazi, Jasmine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.