How maternal viruses and HIV affect infant gut health and immunity
Influence of maternal virome and HIV status on infant gut virome, growth and immunity
This study looks at how the viruses from mothers with HIV can affect the gut viruses in their babies, helping us understand how this might influence the babies' growth and immune health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10906878 on NIH RePORTER |
What this research studies
This research investigates how the viruses present in mothers, particularly those living with HIV, influence the gut viruses of their infants. It aims to understand the transmission of maternal virome to infants and how this affects their growth and immune system development. By analyzing the gut virome of infants, the study seeks to uncover the potential health implications for infants born to HIV-infected mothers, who may face unique health challenges. The approach includes advanced sequencing techniques to profile the virome and its effects on infant health.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants born to mothers living with HIV, particularly those who may be at risk for growth and immune system issues.
Not a fit: Patients who are not infants born to HIV-infected mothers or those who do not have concerns related to gut health and immunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for infants born to HIV-infected mothers by enhancing our understanding of their immune development.
How similar studies have performed: While there has been significant research on maternal bacterial microbiota, studies specifically focusing on maternal virome and its impact on infant health are limited, making this approach relatively novel.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Jaspan, Heather Beryl — Seattle Children's Hospital
- Study coordinator: Jaspan, Heather Beryl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.