How maternal stress and oxidative stress affect child asthma risk
Official title: Associations among maternal lifetime psychosocial stress, prenatal systemic and placental oxidative stress mixtures, and child asthma
Funded at Icahn School of Medicine at Mount Sinai · NIH-11070297 · Data updated 2026-11-12
This study looks at how a mother's stress throughout her life might affect her children's chances of developing asthma, especially in families from lower-income BIPOC communities, and aims to find out how these experiences can impact kids' lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 20, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $629,881 |
| NIH project number | 5R01HL164775-03 |
| Project ID | NIH-11070297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women, especially those from lower-income BIPOC backgrounds who have experienced significant life stressors.
✕Less likely to help
Patients who are not pregnant or those without a history of significant psychosocial stress may not benefit from this research.
What this research studies
This research investigates how a mother's lifetime experiences of stress and the resulting oxidative stress may influence the development of asthma in her children. It focuses on understanding the biological mechanisms that link maternal trauma to respiratory health outcomes in children, particularly among lower-income BIPOC populations. By examining the role of oxidative stress and its impact on fetal development, the study aims to identify potential biomarkers that could help explain health disparities in asthma prevalence. The research employs a combination of cohort studies and biological assessments to gather data on these complex interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for asthma in children, particularly in vulnerable populations.
How similar studies have gone: Previous research has shown promising results in understanding the links between maternal stress and child health outcomes, but this specific approach focusing on oxidative stress in BIPOC populations is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Carroll, Kecia Nicole — Icahn School of Medicine at Mount Sinai
- Study coordinator: Carroll, Kecia Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.