How maternal stress affects fetal development differently in males and females
Placental epigenetic mechanisms contributing to sex-specific impacts of maternal stress on fetal development
This study looks at how stress during pregnancy affects the development of baby boys and girls differently, using mice to find out which genes might make boys more sensitive to stress later in life, with the hope of discovering ways to help improve the health of babies before they are born.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10563162 on NIH RePORTER |
What this research studies
This research investigates how stress experienced by mothers during pregnancy can lead to different developmental outcomes for male and female fetuses. Using a mouse model, the study focuses on the placental mechanisms that regulate gene expression in response to maternal stress, particularly how these mechanisms may make male offspring more vulnerable to stress-related issues. The researchers aim to identify specific genes and pathways involved in this process, which could help predict risks for diseases later in life. By understanding these sex-specific responses, the research seeks to uncover potential interventions to improve fetal health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be pregnant individuals experiencing high levels of stress.
Not a fit: Patients who are not pregnant or those who do not experience significant stress during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of stress-related developmental issues in male and female infants.
How similar studies have performed: Other research has shown that understanding the impact of maternal stress on fetal development can lead to significant advancements in prenatal care, indicating that this approach has potential for success.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Bale, Tracy L — University of Colorado Denver
- Study coordinator: Bale, Tracy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.