How maternal stress affects fetal brain development and behavior
Prenatal neuroinflammation: maternal microbiome contributions and behavioral consequences
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11037961
This study looks at how stress during pregnancy can affect both moms and their babies, especially how it might change brain development and lead to behavior problems later on, using mice to learn more about these effects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11037961 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of prenatal stress on both mothers and their developing fetuses, focusing on how stress-induced inflammation can alter brain development and lead to behavioral issues. Using a mouse model, the study examines changes in the maternal microbiome and the role of a specific chemokine, CCL2, in these processes. By understanding these mechanisms, the research aims to uncover how maternal health can influence the long-term neurodevelopment of offspring. The findings could provide insights into preventing psychiatric disorders linked to prenatal stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals experiencing high levels of stress or inflammation.
Not a fit: Patients who are not pregnant or those without any history of stress-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to strategies for improving maternal health and reducing the risk of neurodevelopmental disorders in children.
How similar studies have performed: Previous research has shown that maternal health significantly impacts fetal development, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUR, TAMAR — OHIO STATE UNIVERSITY
- Study coordinator: GUR, TAMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.