How maternal metabolism affects the health and aging of offspring
Investigating the role of maternal metabolic reprogramming in progeny physiology and aging
This study looks at how a mother's metabolism might affect her children's health and aging by examining the egg cells in fruit flies, helping us understand how what moms go through can impact their kids' development and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10884266 on NIH RePORTER |
What this research studies
This research investigates how changes in a mother's metabolism can influence the health and aging of her children. By studying the oocytes (egg cells) in fruit flies, researchers aim to understand the biochemical and metabolic processes that are passed from mother to offspring. The study focuses on how maternal factors can affect the development and lifespan of progeny, potentially leading to metabolic disorders. Through advanced techniques like metabolomics, the research seeks to uncover the underlying mechanisms that link maternal health to the long-term well-being of children.
Who could benefit from this research
Good fit: Ideal candidates for this research are mothers and their children, particularly those concerned about metabolic health and aging.
Not a fit: Patients who are not mothers or do not have children may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing metabolic disorders in children and improving their overall health and longevity.
How similar studies have performed: Previous studies have shown promising results in understanding the impact of maternal health on offspring, but this specific approach using Drosophila is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Sieber, Matthew — Ut Southwestern Medical Center
- Study coordinator: Sieber, Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.