How maternal influence affects brain development and independence in young animals
Maternal Control Over Developing Prefrontal Cortex and Transition in Independence
This study looks at how having a mother around helps young rats learn to switch from feeling safe to feeling scared, which could help us understand how brain development works and why some kids might struggle with learning as they grow up.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10815772 on NIH RePORTER |
What this research studies
This research investigates how the presence of a mother influences the development of brain circuits in young rats, particularly during critical transitions from attachment learning to fear learning. By observing these changes, the study aims to understand the neural mechanisms that support behavioral flexibility in developing organisms. The researchers will use a model involving odor-shock pairings to explore how maternal control impacts the development of specific brain areas, particularly the prefrontal cortex, during a crucial five-day period of learning. This approach may provide insights into the vulnerabilities that can lead to developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include children and adolescents who have experienced developmental challenges or behavioral issues.
Not a fit: Patients who are adults or those without a history of developmental or behavioral concerns may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how early maternal interactions shape brain development and influence behavioral outcomes in children.
How similar studies have performed: Previous research has shown that maternal influence plays a significant role in early brain development, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Sullivan, Regina Marie — New York University School of Medicine
- Study coordinator: Sullivan, Regina Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.