How maternal infections affect the immune development of the fetus
Does the maternal environment during viral infection and inflammation direct fetal T cell development and function?
This study looks at how infections and inflammation in pregnant mothers can affect the development of important immune cells in their babies, which may influence their health later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10825113 on NIH RePORTER |
What this research studies
This research investigates how maternal infections and inflammation during pregnancy can influence the immune system development of the fetus. It focuses on a specific type of immune cell, called γδ T cells, which are crucial for fighting infections and preventing diseases later in life. By examining how these cells develop in response to maternal immune activation, the study aims to understand the long-term effects on the offspring's health. The research employs a combination of laboratory techniques and analysis of immune cell function to uncover these relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who may be experiencing infections or inflammation.
Not a fit: Patients who are not pregnant or those whose immune systems are not affected by maternal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of immune-related diseases in children and adults.
How similar studies have performed: Previous research has shown that maternal immune activation can significantly impact fetal development, suggesting that this approach could yield valuable insights.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Bonney, Elizabeth a. — University of Vermont & St Agric College
- Study coordinator: Bonney, Elizabeth a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.