How maternal HIV infection and cytomegalovirus affect child brain development
The effect of cytomegalovirus, inflammation, and immune activation on neurodevelopment in children exposed to maternal HIV infection
['FUNDING_P01'] · UNIVERSITY OF WASHINGTON · NIH-10381037
This study is looking at how a mother's HIV infection and cytomegalovirus might affect the brain development of their children, especially those who are exposed to HIV but don't have it themselves, to find ways to help support these kids as they grow.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10381037 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of maternal HIV infection and cytomegalovirus (CMV) on the neurodevelopment of children. It focuses on how exposure to these factors in utero may lead to cognitive and developmental challenges in children, particularly those who are HIV-exposed but uninfected. The study will analyze the relationship between maternal immune activation, chronic inflammation, and neurodevelopmental outcomes in children, using a combination of clinical assessments and biological measures. By understanding these connections, the research aims to identify potential interventions to support affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research include children who were exposed to maternal HIV infection and may have been affected by cytomegalovirus.
Not a fit: Patients who are not exposed to maternal HIV or cytomegalovirus are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for monitoring and supporting the development of children exposed to maternal HIV and CMV.
How similar studies have performed: Previous research has shown that early-life infections can significantly impact neurodevelopment, suggesting that this study's approach is grounded in established findings.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SLYKER, JENNIFER ANN — UNIVERSITY OF WASHINGTON
- Study coordinator: SLYKER, JENNIFER ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Morbidity - disease rate