How maternal genetics affect the growth of children over generations
Effect of genomic imprinting in placentas on maternal transmission of growth phenotypes to offspring in a multigenerational human cohort study
This study is looking at how a mother's health and nutrition can affect her child's growth and development, using information collected over 20 years from families in Mali, to help us understand how traits are passed from mothers to their children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11003712 on NIH RePORTER |
What this research studies
This research investigates how genomic imprinting, an epigenetic mechanism, influences the growth and development of children based on their mothers' health and nutrition. By analyzing data collected over two decades from mothers and their offspring in Mali, the study aims to understand the relationship between maternal traits, such as body mass index and growth patterns, and the corresponding growth outcomes in children. The researchers will look at various factors, including age at puberty and developmental milestones, to uncover how these maternal characteristics are passed down to the next generation.
Who could benefit from this research
Good fit: Ideal candidates for this research include mothers and their children from diverse backgrounds, particularly those living in or connected to Mali.
Not a fit: Patients who are not mothers or do not have children may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing non-communicable diseases in future generations by understanding the maternal influences on child growth.
How similar studies have performed: Previous research has shown promising results in understanding the impact of maternal health on child development, making this approach both relevant and potentially impactful.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Strassmann, Beverly Ilse — University of Michigan at Ann Arbor
- Study coordinator: Strassmann, Beverly Ilse
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.