How maternal folate levels affect child development and autism risk
Functional RNA Modifications, Micronutrient Exposure, Developmental Disabilities
['FUNDING_R01'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-10852909
This study is looking at how the amount of folate a mother eats during pregnancy might affect the chances of her child developing autism, and it aims to help us understand how nutrition can influence a child's development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-10852909 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between maternal folate intake and the risk of autism spectrum disorders (ASD) in children. By combining studies on mouse models and human birth cohorts, the research aims to understand how RNA methylation, influenced by folate levels, may play a role in child development. The study will analyze variations in maternal folate levels and their potential effects on RNA and DNA methylation dynamics, which could provide insights into developmental disabilities. Participants may contribute to understanding how nutritional factors during pregnancy can impact child health.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women or mothers with children aged 0-11 years, particularly those concerned about developmental disabilities.
Not a fit: Patients who are not pregnant or whose children are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations for pregnant women to reduce the risk of autism in their children.
How similar studies have performed: Previous studies have shown varying results regarding maternal folate intake and autism risk, indicating that this research could provide valuable new insights into a debated area.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIE, HEHUANG — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: XIE, HEHUANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Child Development Disorders