How maternal factors influence egg development in zebrafish
Official title: Maternal regulation of microtubules in egg developmental competency
Funded at University of Pennsylvania · NIH-10999869 · Data updated 2026-11-12
This study is looking at how things from a mother, like her genes and health, help eggs develop properly in zebrafish, which could give us important clues about fertility and how to improve it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 6, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $243,750 |
| NIH project number | 1R21HD116483-01 |
| Project ID | NIH-10999869 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in reproductive health, particularly those facing challenges related to fertility or egg development.
✕Less likely to help
Patients who are not seeking to conceive or who do not have concerns related to reproductive health may not benefit from this research.
What this research studies
This research investigates the role of maternal factors in the early stages of egg development, particularly focusing on how these factors regulate processes necessary for fertilization and embryonic growth. Using zebrafish as a model organism, the study aims to understand the mechanisms by which maternal contributions affect the activation of eggs and subsequent development. The research employs advanced techniques, including CRISPR, to explore the genetic and cellular processes involved in this regulation. By examining these processes, the study seeks to uncover critical insights into reproductive success and fertility.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of fertility and developmental biology, potentially leading to improved reproductive health strategies.
How similar studies have gone: Previous research has shown success in using zebrafish to study maternal factors in development, indicating that this approach is both valid and promising.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Mullins, Mary C. — University of Pennsylvania
- Study coordinator: Mullins, Mary C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.