How maternal factors influence early embryo development
Maternal transcription factors shaping early embryonic chromatin landscape
This study is looking at how certain proteins from mothers help shape the early development of embryos, using frog eggs to see how genes turn on and off as the embryo grows, which could help us understand how cells become different types in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11030819 on NIH RePORTER |
What this research studies
This research investigates how specific maternal transcription factors affect the early stages of embryonic development by regulating gene expression through epigenetic modifications. By using frog embryos as a model system, the study aims to understand the timing and spatial control of gene activation during the transition from fertilized egg to pluripotent cells. The researchers will employ advanced techniques like ChIP-seq to analyze the binding of transcription factors to DNA and determine which interactions are crucial for proper cellular differentiation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the genetic and epigenetic factors influencing embryonic development, particularly those with a family history of developmental disorders.
Not a fit: Patients with established developmental disorders that are not linked to early embryonic gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of early developmental processes, potentially informing treatments for developmental disorders.
How similar studies have performed: Previous research has shown success in using model organisms like frogs to study embryonic development, indicating that this approach is promising.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Cho, Ken W.y. — University of California-Irvine
- Study coordinator: Cho, Ken W.y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.