How maternal factors influence allergy development in children
Official title: Development of allergy in offspring is enhanced by maternal eicosanoids and lung microbiota composition dysbiosis.
Funded at Indiana University Indianapolis · NIH-10983322 · Data updated 2026-11-12
This study looks at how a mother's health and certain substances in her body can influence whether her children develop allergies and asthma, hoping to find ways to help prevent these conditions in kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | November 8, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $761,923 |
| NIH project number | 5R01AI180448-02 |
| Project ID | NIH-10983322 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have a family history of allergic diseases or asthma.
✕Less likely to help
Patients who do not have a family history of allergies or asthma may not benefit from this research.
What this research studies
This research investigates how maternal health, specifically the presence of certain eicosanoids and the composition of lung microbiota, affects the development of allergies and asthma in their children. By studying animal models, the researchers aim to understand how these maternal factors can lead to increased allergen responsiveness in offspring. The study will explore the mechanisms behind the transmission of allergic reactivity from mothers to their children, focusing on the role of specific substances found in allergic mothers. This research could provide insights into preventing allergic diseases in children.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing allergies and asthma in children, particularly those with a family history of these conditions.
How similar studies have gone: Previous studies have shown that maternal factors can influence allergy development, suggesting that this research builds on established concepts in the field.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Cook-Mills, Joan M — Indiana University Indianapolis
- Study coordinator: Cook-Mills, Joan M
Related research
Other NIH-funded projects on the same topics.
-
How a mom’s inflammatory fats and lung microbes may raise a child’s allergy risk
This project looks at whether higher levels of a type of inflammatory fat (called DHET) and changes in a mother's lung microbes increase a child's chance of developing allergies or asthma.
-
Targeting gut microbes to restore food-tolerance in adults
Aims to understand how gut bacteria and the lining of the gut interact to keep people with food allergies tolerant to what they eat.
-
Fecal microbiome therapy to help older adults recover after brain injury
A trial explores giving a healthy gut microbiome to help people, especially older adults, recover better after a traumatic brain injury.
-
Investigating how gut bacteria affect food allergies in children
This study is looking at how the bacteria in kids' tummies might help their bodies get used to certain foods and avoid allergies, especially as they start eating solid foods after breastfeeding.
-
Exploring gut bacteria treatments for Alzheimer's patients after brain injuries.
This study is looking at how special treatments for gut health might help people with Alzheimer's who have also had brain injuries, by exploring how the bacteria in our gut can affect brain health and memory.
-
The link between gut bacteria and major depressive disorder.
This study is looking at how changes in gut bacteria might affect depression, and it's for people with major depressive disorder who want to understand more about how their gut health could be linked to their mood.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.