How maternal factors influence allergy development in children
Development of allergy in offspring is enhanced by maternal eicosanoids and lung microbiota composition dysbiosis.
This study looks at how a mother's health and certain substances in her body can influence whether her children develop allergies and asthma, hoping to find ways to help prevent these conditions in kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10983322 on NIH RePORTER |
What this research studies
This research investigates how maternal health, specifically the presence of certain eicosanoids and the composition of lung microbiota, affects the development of allergies and asthma in their children. By studying animal models, the researchers aim to understand how these maternal factors can lead to increased allergen responsiveness in offspring. The study will explore the mechanisms behind the transmission of allergic reactivity from mothers to their children, focusing on the role of specific substances found in allergic mothers. This research could provide insights into preventing allergic diseases in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have a family history of allergic diseases or asthma.
Not a fit: Patients who do not have a family history of allergies or asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing allergies and asthma in children, particularly those with a family history of these conditions.
How similar studies have performed: Previous studies have shown that maternal factors can influence allergy development, suggesting that this research builds on established concepts in the field.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Cook-Mills, Joan M — Indiana University Indianapolis
- Study coordinator: Cook-Mills, Joan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.