How maternal exposure to pollutants affects asthma in children
Maternal programming of the stem cell-basophil axis for asthma
This study looks at how being around diesel exhaust and cigarette smoke while pregnant might increase the chances of children developing asthma, using mice to explore how these environmental factors can affect the immune system of the babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10646191 on NIH RePORTER |
What this research studies
This research investigates how exposure to diesel exhaust and cigarette smoke during pregnancy may lead to asthma in children. Using a mouse model, the study examines how maternal environmental factors can program stem cells in offspring to predispose them to asthma. The researchers focus on the role of specific immune cells called basophils, which are influenced by maternal exposure and may contribute to allergic responses and asthma development. By understanding these mechanisms, the research aims to uncover potential pathways for prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have a family history of asthma or have been exposed to environmental pollutants during pregnancy.
Not a fit: Patients who do not have asthma or a family history of allergic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing asthma in children by addressing maternal environmental exposures.
How similar studies have performed: Previous studies have shown a link between maternal environmental exposures and childhood asthma, suggesting that this research builds on established findings rather than exploring a completely novel approach.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Gorska, Magdalena Maria — National Jewish Health
- Study coordinator: Gorska, Magdalena Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.