How maternal diet affects the risk of fatty liver disease in offspring
Role of the Macrophage in Developmentally Programmed NAFLD
This study looks at how what a mom eats while she's pregnant and breastfeeding can affect her child's immune system and possibly their risk of developing liver issues later on, and it aims to find ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10627890 on NIH RePORTER |
What this research studies
This research investigates how a mother's diet during pregnancy and breastfeeding influences the development and function of immune cells in her offspring, which may increase their risk of non-alcoholic fatty liver disease (NAFLD) later in life. The study will analyze changes in immune cell behavior and metabolism in response to maternal diet and explore potential interventions to mitigate these effects. By examining liver health and immune responses in both young and adult offspring, the research aims to uncover the underlying mechanisms linking maternal nutrition to long-term health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are 21 years or older and have a family history of fatty liver disease or related metabolic conditions.
Not a fit: Patients who are not affected by fatty liver disease or do not have a family history of metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing fatty liver disease in individuals whose mothers had poor diets during pregnancy.
How similar studies have performed: Previous research has shown that maternal diet can significantly impact offspring health, suggesting that this approach may yield valuable insights into disease prevention.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Friedman, Jacob E — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Friedman, Jacob E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.