How maternal depression affects infants' stress responses

Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness

NIH-funded research Pennsylvania State University, the · NIH-10401874

This study looks at how a mother's depression can affect her baby's ability to handle stress, helping us understand when and how we can support both moms and their little ones for better emotional health.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionPennsylvania State University, the NIH-funded
Lab location1 site (University Park, United States)
Project IDNIH-10401874 on NIH RePORTER

What this research studies

This research investigates the impact of maternal depression on how infants respond to stress. It aims to understand the physiological systems involved, such as the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system, and how these systems may become dysregulated due to early exposure to maternal depression. By examining the relationship between maternal mental health and infant stress responses, the study seeks to identify critical periods for intervention to improve child emotional and behavioral outcomes.

Who could benefit from this research

Good fit: Ideal candidates for this research include infants aged 0-11 years whose mothers are experiencing depression.

Not a fit: Patients who are not infants or whose mothers do not have depression may not receive benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better understanding and interventions for infants at risk of emotional and behavioral problems due to maternal depression.

How similar studies have performed: Previous research has indicated that maternal mental health significantly influences child development, suggesting that this approach has a foundation in established findings.

Where this research is happening

University Park, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Mental disordersMental health disordersPsychiatric Disease
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.